On the mathematical modeling of the biochemical network that describes the molecular interaction between dendritic cell receptors and the mannose ligand of mycobacterium tuberculosis
Main Article Content
Keywords
Tuberculosis, Dendritic cells, Mycobacterium tuberculosis, ligands, receptors, mathematical modeling
Abstract
At global level, tuberculosis (TB) is considered a disease of great importance in public health with high incidence and mortality rates. Mathematical modeling in the CD-Mtb complex (Dentritic cells-Mycobacterium tuberculosis) has not been studied a lots, above represents a research problem that can be addressed with current advances on modeling at molecular scales, being "the receptor-ligand model with representation of states "the most recommended to address biding dynamics. Additionally, the importance of studies in this field lies in the prediction that would allow modeling in association with the development of an active or latent TB stage. Taking into account the above, this research focused on determining the main receptors that are coupled with the mannose ligand in the molecular recognition process, in addition to formulating, based on the available literature, a biochemical network that couples the molecular interaction between the dendritic cells and the pathogen Mtb in the signaling pathways involving recognition of mannose by dendritic cell receptors (DC-SIGN, TLR4, de TLR9, TLR2, MR, Dectin-2, Mincle, FcRy, Dectin-1, SIGNR -3, CR3, SR, Langerin). It is expected that from this network, mathematical models will be developed through systems of differential equations. This modeling will allow the manipulation of variables and parameters, in order to answer questions about the possible interactions mediated between twelve cell receptors and the mannose ligand.
References
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2- Akira S., Takeda K. and Kaisho T. (2001). Toll-like receptors: critical proteins linking innate and acquired immunity. Nature Immunology, 2(8): 675 - 680
3- Balboa L., Romero M., Yokobori N., Schierloh P., Geffner L., Basile J., Musella R., Abbate E., de la Barrera S., Sasiain M. and Alemán M. (2010). Mycobacterium tuberculosis impairs dendritic cell response by altering CD1b, DC-SIGN and MR profile. Immunology and Cell Biology, 88:716-726
4- Banchereau J. and Steinman R. (1998). Dendritic cells and the control of immunity. Nature, 392: 245 - 252
5- Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y., Pulendran B. and Palucka K. (2000). Immunobiology Of dendritic cells. Annu. Rev. Immunol, 18:767-811
6- Bansal K., Elluru S., Narayana Y., Chaturvedi R., Patil S., Kaveri S., Bayry J. and Balaji K. (2010). PE_PGRS Antigens of Mycobacterium tuberculosis Induce Maturation and Activation of Human Dendritic Cells. J. Immunol, 184;3495-3504
7- Buschow S., Lasonder E., van Deutekom H., Oud M., Beltrame L., Huynen M., de Vries I., Figdor C. and Cavalieri D. (2010). Dominant Processes during Human Dendritic Cell Maturation Revealed by Integration of Proteome and Transcriptome at the Pathway Level. Journal of Proteome Research, 9:1727-1737
8- Chávez D. (2007). Receptores Tipo Toll. Rev. latinoam. actual. bioméd., 1(1): 3-9
9- Chavesa M., Sontag E. and Dinerstein R. (2004). Steady-States of Receptor-Ligand Dynamics: A Theoretical Framework. Preprint submitted to Elsevier Science
10- Chen K., Lu J., Wang L. and Gan YW. (2004). Mycobacterial heat shock protein 65 enhances antigen cross-presentation in dendritic cells independent of Toll-like receptor 4 signaling. J. Leukoc. Biol., 75: 260 -266
11- Dietrich J. and Doherty M. (2009). Interaction of Mycobacterium tuberculosis with the host: consequences for vaccine development. APMIS, 117: 440-457
12- Eungdamrong N. and Lyengar R. (2004). Modeling Cell Signaling Networks. Biology of the Cell, 96: 355-362
13- Geijtenbeek T., van Vliet S., Koppel E., Sanchez-Hernandez M., Vandenbroucke-Grauls C., Appelmelk B. and van Kooyk Y. (2002). Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function. J. Exp. Med., 197(1): 7 - 17
14- Gringhuis S., Dunnen J., Litjens M., Hof B., van Kooyk Y. and Geijtenbeek T. (2007). C-Type Lectin DC-SIGN Modulates Toll-like Receptor Signaling via Raf-1 Kinase-Dependent Acetylation of Transcription Factor NF-Kb. Immunity, 26: 605-616
15- Gurevich K. (2004). Application of methods of identifying receptorbinding models and analysis of parameters. Theoretical Biology and Medical Modelling, 1:11
16- Henderson, R.A. Watkins S.C. and Flynn JL. (1997). Activation of human dendritic cells following infection with Mycobacterium tuberculosis. The Journal of Immunology, 159(2) : 635-643.
17. Ibarguen-Mondragon E, Esteva Lourdes, Burbano-Rosero E. (2017). Mathematical model for the growth of mycobacterium tuberculosis in the granuloma. Mathematical Biosciences and Engineering, 13 (5), 407-428.
18. Ibarguen-Mondragon E., Esteva L., Chavez-Galán Leslie (2011). A mathematical model for cellular immunology of tuberculosis. Mathematical Biosciences and Engineering, 8 (4), 973-986.
19. Ibarguen-Mondragon E., Esteva L. (2014). On the interactions of sensitive and resistant Mycobacterium, Mathematical Biosciences 246 (2013) 84–93
20. Ibarguen-Mondragon E., Esteva L. (2014). On CTL response against Mycobacterium tuberculosis, Applied Mathematical Sciences, 8 (48), 2383-2389.
21. Kirschner D., Chang S., Riggs T., Perry N. and Linderman J. (2007). Toward a multiscale model of antigen presentation in immunity. Immunological Reviews, 216: 93-118
22. Klein P., Mattoon D., Lemmon M. and Schlessinger J. (2003). A structure-based model for ligand binding and dimerization of EGF receptors. PNAS, 101(4): 929 - 934
23. Klotz I. and Hunston D. (1984). Mathematical Models for Ligand-Receptor Binding. The Journal Of Biological Chemistry, 259(16): 10060 - 10062
24. Lewinsohn D., Grotzke J., Heinzel A., Zhu L., Ovendale P., Johnson M. and Alderson M. (2006). Secreted Proteins from Mycobacterium tuberculosis Gain Access to the Cytosolic MHC Class-I Antigen-Processing Pathway. The Journal of Immunology, 177: 437- 442
25. Li Q., Singh C., Ma S., Price N. and Jagannath C. (2011). Label-free proteomics and systems biology analysis of mycobacterial phagosomes in dendritic cells and macrophages. J Proteome Res, 10(5): 2425-2439
26. Liu, K. (2006). Dendritic Cell, Toll-Like Receptor, and The Immune System. Journal of Cancer Molecules, 2(6): 213-215
27. Mortellaro A., Robinson L. and Ricciardi-Castagnoli P. (2009). Spotlight on mycobacteria and dendritic cells: will novel targets to fight tuberculosis emerge?. EMBO mol. med., 1: 19 - 29
28. Pérez M. (2006). Procesamiento y presentación de antígeno por moléculas MHC clase I y clase II. Rev. Med. Inst. Mex., 44(2): 7-10
29. Savina A. and Amigorena S. (2007). Phagocytosis andantigen presentation in dendritic cells. Immunological Reviews, 219: 143-156
30. Serrano-Gómez D., Martínez-Nuñez R., Sierra-Filardi E., Izquierdo N., Colmenares M., Pla J., Rivas L., Martinez-Picado J., Jimenez-Barbero J., Alonso-Lebrero J., González S. and Corbí A. (2007). AM3 Modulates Dendritic Cell Pathogen Recognition Capabilities by Targeting DC-SIGN. Antimicrobial Agents and Chemotherapy, 51(7): 2313-2323
31. Wigginton J. and Kirschner D. (2001). A Model to Predict Cell-Mediated Immune Regulatory Mechanisms During Human Infection with Mycobacterium tuberculosis. The Journal of Immunology, 166: 1951-1967
32. Behler, F., Maus, R., Bohling, J., Knippenberg, S., Kirchhof, G., Nagata, M., … Maus, U. A. (2015). Macrophage-Inducible C-Type Lectin Mincle-Expressing Dendritic Cells Contribute to Control of Splenic Mycobacterium bovis BCG Infection in Mice. Infection and Immunity, 83(1), 184–196. http://doi.org/10.1128/IAI.02500-14 .
33. Mihret, A. (2012). The role of dendritic cells in Mycobacterium tuberculosis infection. Virulence, 3(7), 654–659. http://doi.org/10.4161/viru.22586 .
34. Inaba K, Pack M, Inaba M, Sakuta H, Isdell F, Steinman RM. High levels of a major histocompatibility complex II-self peptide complex on dendritic cells from the T cell areas of lymph nodes. J. Exp. Med. 186: 665-72 (1997).
35. Guery JC, Adorini L. Dendritic cells are the most effi cient in presenting endogenous naturally processed self-epitopes to class II-restricted T cells. J. Immunol. 154: 536-44 (1995).
36. Sallusto F, Lanzavecchia A. Mobilizing dendritic cells for tolerance, priming, and chronic inflammation. J. Exp. Med. 189: 611-4 (1999); Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18: 767-811 (2000).
37. Orabona C, Grohmann U, Belladonna ML, Fallarino F, Vacca C, Bianchi R, Bozza S, Volpi C, CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86, Nature immunology, 5 (11), 1134-1142.
38. Ma DY, Clark EA. The role of CD40 and CD154/CD40L in dendritic cells. Semin. Immunol. 21:265-72 (2009) .
39. Johnson JG, Jenkins MK. Co-stimulatory functions of antigen-presenting cells. J. Invest. Dermatol. 99: 62S-65S (1992).
40. Reis e Sousa C. Dendritic cells in a mature age. Nat Rev Immunol. 6: 476-83 (2006).
41. Figdor CG, van Kooyk Y, Adema GJ. C-type lectin receptors on dendritic cells and Langerhans cells. Nat Rev Immunol. 2: 77-84 (2002),
42. Geijtenbeek TB, Engering A, Van Kooyk Y. DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J. Leukoc. Biol. 71: 921-31 (2002).
43. Romero-Palomo, F., Sánchez Cordón, P., Risalde, M., Pedrera, M., Molina, V., Ruiz-Villamor, E., Gomez-Villamandos, J. (2011). Funciones y clasificación de las células dentríticas. Real Academia de Ciencias Veterinarias de Andalucia Oriental. Vol (24): 167-191.
44. Clark GJ, Angel N, Kato M, Lopez JA, MacDonald K, Vuckovic S, Hart DN. The role of dendritic cells in the innate immune system. Microbes Infect. 2: 257-72 (2000); -Reis e Sousa C. Activation of dendritic cells: translating innate into adaptive immunity. Curr. Opin. Immunol. 16: 21-5 (2004) .
45. Reis e Sousa C. Dendritic cells as sensors of infection. Immunity. 14: 495-8 (2001).
46. Reis e Sousa C. Activation of dendritic cells: translating innate into adaptive immunity. Curr. Opin. Immunol. 16: 21-5 (2004); Reis e Sousa C. Toll-like receptors and dendritic cells: for whom the bug tolls. Semin. Immunol. 16: 27-34 (2004).
47. Moser M, Murphy KM. Dendritic cell regulation of TH1-TH2 development. Nature immunology.1: 199-205 (2000) .
48. McKenna K, Beignon AS, Bhardwaj N. Plasmacytoid dendritic cells: linking innate and adaptive immunity. J. Virol. 79: 17-27 (2005); Diebold SS, Montoya M, Unger H, Alexopoulou L, Roy P, Haswell LE, Al-Shamkhani A, Flavell R, Borrow P, Reis e Sousa C. Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature. 424: 324-8 (2003) .
49. Huang FP, MacPherson GG. Continuing education of the immune system--dendritic cells, immune regulation and tolerance. Curr Mol Med. 1: 457-68 (2001); Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21: 685-711 (2003) .
50. Steinman RM, Nussenzweig MC. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. U. S. A. 99: 351-8 (2002) .
51. Roncarolo MG, Levings MK, Traversari C. Differentiation of T regulatory cells by immature dendritic cells. J. Exp. Med. 193: F5-9 (2001)
52. Guevara-Guzmán A, Juárez-Hernández A, Zenteno-Cuevas R.Tuberculosis y la importancia de incorporar nuevas metodologías diagnósticas. MedUNAB 2003; 6 (16): 46-51.
53. Gorocica P, Jiménez-Martínez MC, Garfias Y, Sada I, Lascurain R. Componentes glicosilados de la envoltura de Mycobacterium tuberculosis que intervienen en la patogénesis de la tuberculosis. Rev Inst Nal Enf Resp Mex 2005; 18(2): 142-153 .
54. Mendelson M, Hanekom W, Kaplan G. Dendritic cells in host immunity to Mycobacterium tuberculosis. In: Cole St, Eisenach KD, McMurray DN, Jacobs Jr WR. Tuberculosis and the tubercule bacillus. Washington, DC, USA: ASM Press, 2005: 451-461 .
55. Mitchell A. Yakrus, Jeffrey Driscoll, Allison McAlister, et al., “Molecular and Growth-Based Drug Susceptibility Testing of Mycobacterium tuberculosis Complex for Ethambutol Resistance in the United States,” Tuberculosis Research and Treatment, vol. 2016, Article ID 3404860, 5 pages, 2016. doi:10.1155/2016/3404860.
56. Tailleux L, Schwartz O, Herrmann JL, Pivert E, Jackson M et al. DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. J Exp Med 2003; 197 (1): 121-127.
57. Tang Z, Roberts C, Chang C, Bhardwaj N, (2017), Understanding ligand-receptor non-covalent binding kinetics using molecular modeling, Front Biosci (Landmark Ed), 2017; 22: 960–981.
58. Underhill DM, Ozinsky A. Toll-like receptors: Key mediators ofmicrobe detection. Curr Opin Immunol 2002; 14 (1): 103-110
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Feb 1, 2021
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On the mathematical modeling of the biochemical network that describes the molecular interaction between dendritic cell receptors and the mannose ligand of mycobacterium tuberculosis. bol.redipe [Internet]. 2021 Feb. 1 [cited 2024 Nov. 24];10(2):109-30. Available from: https://revista.redipe.org/index.php/1/article/view/1199
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Author Biographies
Eduardo Ibarguen Mondragón, University of Nariño, Colombia
Department of Mathematics and Statistics, University of Nariño, Pasto, Colombia
Edith Mariela Burbano-Rosero, University of Nariño, Colombia
Department of Biology, University of Nariño, Pasto, Colombia.
Mawency Vergel-Ortega, Francisco de Paula Santander University, Colombia
Department of Mathematics and Statistics, Francisco de Paula Santander University, Norte de Santander, Cúcuta, Colombia.
How to Cite
1.
On the mathematical modeling of the biochemical network that describes the molecular interaction between dendritic cell receptors and the mannose ligand of mycobacterium tuberculosis. bol.redipe [Internet]. 2021 Feb. 1 [cited 2024 Nov. 24];10(2):109-30. Available from: https://revista.redipe.org/index.php/1/article/view/1199